Paul E. Love: A Closer Look into Dr. Love’s Lab

Paul E. Love: A Closer Look into Dr. Love’s Lab

Paul E. Love: A Closer Look into Dr. Love’s Lab

American Board Certified Clinical Pathologist and immunologist Paul Earnest Love, M.D, Ph.D. serves as a Senior Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health.


Love earned a B.S. degree in Biochemistry from Syracuse University and is the recipient of an M.D. and Ph.D. from the Medical Scientist Training Program at the University of Rochester, Rochester, NY. During his 31 years as an investigator at NIH, Dr.Love has made numerous contributions to the field of immunology.


Love served as a Section Editor for the Journal of Immunology, and from 2009 to 2013, he was Chair of the Journal of Immunology Publications Committee. Moreover, starting as review editor in 2015, Dr. Love quickly rose to become an Associate Editor in T cell biology for the journal Frontiers in Immunology.


Independent Research

In 1989, Dr. Love joined Heiner Westphal's Laboratory at the National Institutes of Health as a post-doctoral research fellow. Following completion of his fellowship, he started his own laboratory in NICHD and was promoted to tenured Senior Investigator in 1998. Dr.Love's Laboratory, which is located at the National Institutes of Health's main campus in Bethesda, Maryland, is focused on the development of the mammalian hematopoietic system.


Leading the section on Hematopoiesis and Lymphocyte Biology, Dr. Love’s research has centered primarily on clarifying the cellular and molecular processes that are responsible for regulating T lymphocyte development. Current studies in his laboratory are focused in three main areas.


The first area of research, representing a long-term effort, is devoted to studying the function of the T cell antigen receptor (TCR), the primary activating receptor expressed by T cells. A particular emphasis of research is focused on the individual TCR signal transducing subunits, the sequences responsible for signal transduction, and role of TCR signals in T cell development.


Through transgenic and gene targeting technology, the Love lab has generated several genetically altered mouse strains. Researchers in Love lab have utilized this approach to analyze the function of key genes in T cell development and for T cell activation.


The second area of study involves the identification and characterization of other signaling molecules that perform important roles in T cell development. The goal of this research is to develop a complete road map of the genes and proteins involved in T cell maturation. Moreover, this study is designed to elucidate the molecules and signals that contribute to a critical step of thymocyte development called positive selection. Several of the molecules identified and characterized by the Love lab have been identified as immunotherapy candidates for treating human cancers or autoimmune diseases.


The third area of investigation is a recently initiated project that focuses on understanding the role of a nuclear adapter protein called Ldb1 in hematopoiesis. Through this study the Love lab has established a critical role for Ldb1 in erythropoiesis and in hematopoietic stem cell maintenance and self-renewal. These studies also hold the potential to provide new insights into the pathogenic mechanisms responsible for T cell leukemia.


Dr. Love believes that The growing demand for innovative products within the immunology sector will expand research opportunities which can ultimately result in improving the state of the immunology market.

Published by Peter Jason

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